We review briefly (1) the history of patient-physician relationship and its evolution from a

physician-centered to patient-centered model; (2) the impact of the McDonald Criteria for

Multiple Sclerosis (MS); (3) why it is important to tell patients of their diagnosis; (4) how

physicians should disclose the diagnosis to patients; (5) dealing with suspected MS; and

(6) prognosis and treatment. For the majority of clinically definite MS patients we advocate

disclosure, identify steps for physicians to communicate the diagnosis and propose a framework

to follow when revealing a diagnosis of MS.